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03-19

Optipharm: using the technology of different islets of Langerhans to seize the market of biological agents for diabetes treatment in China

SouthKoreanlifesciencefirmoptipharmwillusexenoislettechnologytoenterthe27trillionwonChinesediabetestreatmentmarket,accordingtoSouthKoreanportalnaver.Optipharm,aSouthKoreanlifesciencecompany,willusethetechnologyofdifferentisletsofLangerhanstoenterthe27trillionwonChinesediabetestreatmentmarket,accordingtoSouthKoreanportalnaaver.SouthKoreanlifesciencefirmoptipharmwillusexenoislettechnologytoenterthe27trillionwonChinesediabetestreatmentmarket,accordingtoSouthKoreanportalnaver.SouthKoreanlifesciencefirmoptipharmwillusexenoislettechnologytoenterthe27trillionwonChinesediabetestreatmentmarket,accordingtoSouthKoreanportalnaver.SouthKoreanlifesciencefirmoptipharmwillusexenoislettechnologytoenterthe27trillionwonChinesediabetestreatmentmarket,accordingtoSouthKoreanportalnaver.SouthKoreanlifesciencefirmoptipharmwillusexenoislettechnologytoenterthe27trillionwonChinesediabetestreatmentmarket,accordingtoSouthKoreanportalnaver.SouthKoreanlifesciencefirmoptipharmwillusexenoislettechnologytoenterthe27trillionwonChinesediabetestreatmentmarket,accordingtoSouthKoreanportalnaver.SouthKoreanlifesciencefirmoptipharmwillusexenoislettechnologytoenterthe27trillionwonChinesediabetestreatmentmarket,accordingtoSouthKoreanportalnaver.
Optipharm: using the technology of different islets of Langerhans to seize the market of biological agents for diabetes treatment in China
03-19

Professor Wang Wei's team of Xiangya Third Hospital of Central South University won another good performance at the World Conference on xenotransplantation

OnOctober10-13,2019,the15thAnnualMeetingoftheWorldAssociationforxenotransplantationwasheldinMunich,Germany.ProfessorWangWei,celltransplantationcenterofXiangyaThirdHospital,CentralSouthUniversity,wasinvitedtoattendthemeetingandgaveanimportantlecture. Thisconferencecoversseveralhottopics,suchas"basicresearchonxenotransplantation","transplantationimmunity","celltransplantationimage","safedonorpig"and"currentsituationofxenotransplantation".ItinvitedProfessorLeoBühler,Presidentoftheworldsocietyforxenotransplantation,andBruno,directorofWolterbrundelexperimentalmedicalcenter,UniversityofMunichMorethan40well-knownexpertsandscholarsinthefieldofxenotransplantation,includingProfessorreicharandProfessorEckhardwolf,directoroftheanimalcenteroftheUniversityofMunichGeneCenter,conductedacademicexchangesaroundtheimportantxenotransplantationdirectionsofheart,kidneyandisletcells,andheldabout100lectures.AsapioneerofxenotransplantationresearchinChina,ProfessorWangWeiwasinvitedtogiveaspeciallectureon"clinicalisletxenotransplantationinChina".ProfessorWangWei'steammadethreeoralspeechesandninewallnewspaperpresentationsattheconference.MaXiaoqian,anassociateresearcher,wonthe"scienceawardofInternationalTransplantationAssociation"awardedbytheconference,becomingoneofthetenwinnersintheworldandtheonlyoneinChina.
Professor Wang Wei
03-19

Wang Wei: a pathfinder of xenotransplantation

GuangmingDailyreporterlongJunyuAihua The36yearoldmaXiaojun(pseudonym)suffersfromtypeIdiabetes.Ifheeatsacorn,hisbloodsugarwillexceedthestandard.Heneedstotakealargedoseofinsulineverydaytoreducehisbloodsugar.AfterreceivingislettransplantationinXiangyathirdhospitalaofCentralSouthUniversity,MaXiaojun'sinsulininjectiondecreasedby80%,hislifereturnedtonormal,andhewasabletogoouttowork. "Hownicetoliveeasily!"MaXiaojunsaidthatthankstoProfessorWangWeiforallthis. WangWeiisaradiologistintheThirdXiangyaHospital.Hislong-termclinicalexperiencehasmadehimknowthatthepaincausedbydiabetesishardforordinarypeopletoimagine.TypeIdiabetesisthemostdifficult.Becauseoftheunstablebloodglucose,itwillleadtoavarietyoflife-threateningcomplications. Islettransplantationisoneofthemostlikelymethodstocurediabetes.However,theextremeshortageofhumandonorsmakesthispossibilitymoreandmoreremote. Canweusetheinterventionmethodtotreatdiabetesmellituswithisletcelltransplantationofanimalsotherthanhuman?Medicalscientistsallovertheworldgraduallyfocusonanimals,especiallypigs.Theresultsshowthatthereisonlyoneaminoacidinpiginsulinmoleculewhichisdifferentfromhumaninsulin,whichmakespigisletxenotransplantationthemostlikelycurefordiabetesintheworldandthehopeoflarge-scaleapplication. In1995,WangWeidecidedtoturntoxenotransplantation.Inthisyear,XiangyaThirdHospitalsupportedWangWei's100000yuanscientificresearchfund,launchedthepreliminaryresearchofislettransplantation,andestablishedtheislettransplantationlaboratory.Sincethen,WangWeibegantodevotehimselftotheresearchonthetreatmentofdiabetesbyislettransplantation,andtheresearchgrouphasalsobecomeoneoftheinternationalacademicteamsthatfirstcarriedoutrelevantresearch. (isletcells) After4yearsofresearch,WangWei'steamachievedabreakthroughinthetreatmentofdiabetesbyintrahepatictransplantationofporcinepancreaticislandcellsviahepaticartery.WiththeapprovaloftheformerMinistryofhealth,WangWei'steamcompleted22clinicaltrialsof"pighuman"islettransplantationindiabetespatientsfrom2000to2004,andachievedsignificanttherapeuticeffects.Theresultsshowedthattheinsulinuseof20patientswasreducedbymorethan30%,whichwas"effective";6of20patientswerereducedbymorethan50%,whichwas"significanteffect";oneofthemwas"temporarilycured"foroneweek. In2005,WangWei'steamalsoachievedthreemajorbreakthroughs:creatingasafermethodofliverarterytransplantationinsteadofportalveinimplantation,findingobviousdifferencesinsideeffectsamongdifferenthumanspeciesinantirejectiontreatment,andexploringdifferentantirejectiontreatmentmethodsinxenotransplantationandhomotransplantationofisletsofLangerhans.InMayofthesameyear,WangWei'sClinicalResearchReportonthetreatmentoftypeIdiabetesmellituswithporcineisletcelltransplantationwashighlypraisedatthe9thAnnualMeetingoftheInternationalAssociationofpancreasislettransplantationheldinGeneva,Switzerland.InAugust,ProfessorCarlgross,whowasthechairmanoftheNobelPrizeforphysiologicalmedicine,praisedWangWeiforhis"pioneeringwork". Therearetoomanyhardshipsandsweatbehindthehalo. Inordertofindthemostsuitablepigprovenance,WangWeiwentuptotheQinghaiTibetPlateauinthenorthanddowntoHainanIslandinthesouth,andscreeneddozensofpigprovenancesinremotevillagesinmorethantenprovinces.Inrecentyears,WangWeihastraveledtensofthousandsofmiles,collectedandstudied11uniquepurepigbreedsinChina,selectedthemostsuitablepigsourcefortransplantation,andestablishedtwoinitialpigsourcebasesinHunanProvince. (xenograftdonorpig) Attheendof2012,WangWei'steamestablishedtheworld'ssecondDPFdonorpigbreedingcenterinChangsha.In2013,theclinicalstudyofxenotransplantationofisletsofLangerhanswasapprovedbythecompetentdepartmentofthegovernment.In2016,itpassedthemid-termreviewoftherapeuticeffectbyexpertsorganizedbythehealthandFamilyPlanningCommissionofHunanProvince.In2017,itpassedthefinalreviewoftherapeuticeffectbyexpertsorganizedbythehealthandFamilyPlanningCommissionofHunanProvince.Thismeansthatxenotransplantationcanfinallyentertheclinicalpractice,benefitingtensofmillionsofordinarypatients. Withtheproblemofscientificresearchbeingsolvedonebyone,abiggerproblemappearedinfrontofWangWei,thatis,thenorm.TheconscienceandsenseofresponsibilityofscientistsalwaysremindWangWeithatxenotransplantationisamajorsubjectandhasgreatbusinessopportunities.Withoutaunifiedandstrictinternationalstandard,itisverydangerousandcontrarytotheoriginalintentionofscientificresearch. Atthebeginningof2006,WangWeistartedthetransformationandinnovationfromthepuretechnicalandtheoreticalresearchofxenotransplantationtotherelatedresearchofestablishinginternationalstandardizedpreclinicalresearchofxenotransplantation,andtooktheleadintheinvestigationofformulatingxenotransplantationnormsinChina.InNovember2008,the"InternationalSymposiumonclinicalresearchnormsofglobalxenotransplantation"washeldinXiangyaThirdHospital,whichformulatedtheChangshadeclaration,aglobalxenotransplantationprogrammaticdocument.Forthefirsttime,theinternationalmedicalclinicalnormswerebrandedwith"Chinesestamp". (Changshadeclaration) InDecember2018,theThirdWorldHealthOrganizationSymposium
Wang Wei: a pathfinder of xenotransplantation
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